Dmitry A. Gordenin

1997 – Current (2009) – Staff Scientist, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; 1996 - present Editorial Board Member, Mutation Research

EDUCATION and WORK in RUSSIA

1973- M.S.; 1978-Ph.D.; 1978-1997 – work at the Department of Genetics, SPbSU, Russia.

SELECTED Ph.D. and POST-DOCTORAL TRAINEES (currently at faculty or senior industry positions): Yury O. Chernoff (1984); Anna L. Malkova (1993); Kirill S. Lobachev (1996); Natalya P. Degtyareva (1997); Tran Hiep (1999); Yong Hwan Jin (2003); Francesca Storici (2007).

SELECTED PUBLICATIONS (findings)

• Gordenin, D.A., Malkova, A.L., Peterzen, A., Kulikov, V.N., Pavlov, Y.I., Perkins, E., Resnick, M.A. 1992. Transposon Tn5 excision in yeast: The influence of DNA polymerase and repair genes. Proc. Natl. Acad. Sci. USA, v. 89, 3785-3789 (replication slippage facilitated by DNA structure and polymerase defects in eukaryotes).

• Hiep T. Tran, J. D. Keen, M. Kricker, M. A. Resnick and D. A. Gordenin. 1997. Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants. Mol. Cell. Biol., v. 17, 2859-2865 (mechanism replicative of instability in microsatellites via escape from polymerase proofreading)

• K.S. Lobachev, D. A. Gordenin and M. A. Resnick. 2002. The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell v. 108, 183-193 (novel type of spontaneous DNA double-strand breaks, which are especially difficult to repair).

• Jin Y.H., Clark A.B., Slebos R.J., Al-Refai H., Taylor J.A., Kunkel T.A., Resnick M.A., and Gordenin D.A. 2003. Cadmium is a mutagen that acts by inhibiting mismatch repair. Nature Genetics, v. 34, 326-329 (high level of environmental mutagenesis via inhibiting DNA repair).

• Jin Y.H., Garg P., Stith C.M.W., Hanan Al-Refai, Sterling J. F., Murray L.J.W., Kunkel T.A., Resnick M.A., Burgers P.M. and D. A. Gordenin. 2005. The multiple biological boles of the 3’5’-exonuclease of yeast DNA polymerase  require switching between the polymerase and exonuclease domains. Mol. Cell. Biol. v. 25, 461-471 (this paper and references therein – two novel biological roles for classical "proofreading" exonuclease within eukaryotic replicative DNA polymerase).

• Storici F, Bebenek K., Kunkel T.A., Gordenin D.A. and Resnick M.A. 2007. RNA-templated DNA repair. Nature, v. 447, 338-341. (DNA double-strand breaks repaired by RNA).

• Yang Y., Sterling J., Storici F., Resnick M.A., and Gordenin D.A. 2008. Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genetics, v. 4 (11):e1000264 (phenomenon of damage-induced localized hypermutability).