Образование, ученые степени и звания 

Карьера 

Научные интересы:

Биофизические механизмы мышечного сокращения. Врожденные миопатии.

Читаемые курсы:

Бакалавриат

• Биоэнергетика

Магистратура

• Биофизика мышечного сокращения
• Врожденные миопатии

Избранные публикации :

• Y.S. Borovikov, D.D. Andreeva, S.V. Avrova, V.V. Sirenko, A.O. Simonyan, C.S. Redwood, O.E. Karpicheva. Molecular mechanisms of the deregulation of muscle contraction induced by the R90P mutation in Tpm3.12 and the weakening of this effect by BDM and W7. Int. J. Mol. Sci. 2021. V. 22. 6318. https://doi.org/10.3390/ijms22126318
• Borovikov, Y. S., Karpicheva, O. E., Avrova, S. V., Simonyan, A. O., Sirenko, V. V., Redwood, Ch. S. The molecular mechanism of muscle dysfunction associated with the R133W mutation in Tpm2.2. Biochemical and Biophysical Research Communications. 2020. V.523. No.1. P. 258-262.
• Borovikov, Y.S., Simonyan, A. O., Avrova, S. V., Sirenko, V.V., Redwood, C.S., Karpicheva, O.E. Molecular mechanisms of muscle weakness associated with E173A mutation in Tpm3.12. Troponin Ca2+ sensitivity inhibitor W7 can reduce the damaging effect of this mutation. International J. Mol. Sci. 2020. V. 21. no. 12. 4421. doi:10.3390/ijms21124421
• Karpicheva, O.E., Simonyan, A.O., Rysev, N.A., Redwood, C.S. Borovikov, Y.S. 2020. Looking for targets to restore the contractile function in congenital myopathy caused by Gln147Pro tropomyosin. International J. Mol. Sci. Vol. 21. 7590. doi:10.3390/ijms21207590
• Avrova, S. V., Karpicheva, O. E., Simonyan, A. O., Sirenko, V. V., Redwood, C. S., Borovikov, Y. S. The molecular mechanisms of a high Ca2+-sensitivity and muscle weakness associated with the Ala155Thr substitution in Tpm3.12. Biochemical and Biophysical Research Communications. 2019. V. 515. № 2. P. 372-377.
• Simonyan А.О., Sirenko V.V., Karpicheva O.E., Robaszkiewicz K., Śliwinska M., Moraczewska J., Krutetskaya Z.I., Borovikov, Y.S. The primary cause of muscle dysfunction associated with substitutions E240K and R244G in tropomyosin is aberrant behavior of tropomyosin and response of actin and myosin during ATPase cycle. Archives of Biochemistry and Biophysics. 2018. V. 644. P. 17-28.
• Rysev N.A., Karpicheva O.E., Sirenko V.V., Simonyan А.О., Redwood C.S., Borovikov Y.S. The effect of the Arg91Gly and Glu139del mutations in β-tropomyosin associated with congenital myopathy of human skeletal muscles on actin–myosin interaction. Cell and Tissue Biology. 2018. V. 12. N. 3. P. 238-246.
• Avrova S.V., Karpicheva O.E., Rysev N.A., Simonyan, А.О., Sirenko V.V., Redwood C.S., Borovikov Y.S. The reason for the low Ca2+-sensitivity of thin filaments associated with the Glu41Lys mutation in the TPM2 gene is “freezing” of tropomyosin near the outer domain of actin and inhibition of actin monomer switching off during the ATPase cycle. Biochemical and Biophysical Research Communications. 2018. V. 502, N. 2. P. 209-214.
• Borovikov Y.S., Karpicheva O.E., Simonyan A.O., Avrova S.V., Rogozovets E.A., Sirenko V.V., Redwood C.S. The primary causes of muscle dysfunction associated with the point mutations in Tpm3.12; conformational analysis of mutant proteins as a tool for classification of myopathies. International Journal of Molecular Sciences. 2018. V. 19, N. 12. P. 3975-4005.
• A. Simonyan, Z. Krutetskaya, L. Milenina, A. Melnitskaya, N. Krutetskaya, V. Antonov. Pyrazole derivative, immunosuppressant YM-58483, inhibits store-operated Ca2+ entry in peritoneal macrophages. FEBS Open Bio. V. 12. Supplement 1. FEBS Press and John Wiley & Sons Ltd. 2022. P. 194.
• A.O. Simonyan, Z.I. Krutetskaya, L.S. Milenina, A.V. Melnitskaya, N.I. Krutetskaya, V.G. Antonov. Sigma-1 receptor ligand trifluoperazine attenuates Ca2+ responses induced by immunomodulators glutoxim and molixan in macrophages. FEBS Open Bio. 2021. V. 11. (Supplement 1). P. 215.
• Simonyan A.O., Krutetskaya Z. I., Milenina L. S., Melnitskaya A. V., Krutetskaya N. I., Antonov V. G. Sigma-1 receptor antagonist chlorpromazine inhibits Ca2+ responses induced by glutoxim and molixan in peritoneal macrophages. 2019, FEBS Open Bio. Vol. 9, Supplement 1, P. 172-173.